Writ large: Genomic dissection of the effect of cellular environment on immune response

Cells of the immune system routinely respond to cues from their local environment and feed back to their surroundings through transient responses, choice of differentiation trajectories, plastic changes in cell state, and malleable adaptation to their tissue of residence. Genomic approaches have opened the way for comprehensive interrogation of such orchestrated responses. Focusing on genomic profiling of transcriptional and epigenetic cell states, we discuss how they are applied to investigate immune cells faced with various environmental cues. We highlight some of the emerging principles on the role of dense regulatory circuitry, epigenetic memory, cell type fluidity, and reuse of regulatory modules in achieving and maintaining appropriate responses to a changing environment.These provide a first step toward a systematic understanding of molecular circuits in complex tissues

Perbedaan Nilai Range of Motion (Rom) Sendi Ekstremitas Atas Sebelum Dan Sesudah Pelatihan Senam Lansia Menpora Pada Kelompok Lansia Kemuning Banyumanik, Semarang

Background: Higher life expectancy led to increasing number of elderly and health problems, including difficulty in ADL\u27s and IADL\u27s activities. Getting older, flexibility decreases, while MENPORA elderly gymnastics is a form of exercise that is easy for the elderly to improve their range of motion (ROM). Objective: Proving MENPORA elderly gymnastics training can increase value of upper limb joints\u27 ROM in Kemuning elderly group, Banyumanik, Semarang. Methods: The study is one group pretest-posttest quasi-experimental design. Samples are elderly people in Kemuning, Banyumanik, Semarang, who met inclusion criteria and no exclusion criteria (n=11); upper limb joints\u27 ROM were measured with universal goniometer. Data distribution tested with Saphiro- Wilk. Normal distribution tested with paired T-test, while abnormal distribution tested with Wilcoxon test. Results : The upper limb joints\u27 ROM difference on the elderly after MENPORA elderly gymnastics are : articulatio humeri: abduction : right: (-24.545±11.058°) ,p=0.00, left: -24.909±11.058°, p=0.00; adduction:right:(-10.909±11.794°), p=0.012, left:(-17.727±13.850°),p=0.002; flexion: right:(-18 636±16.747°), p= 0.012, left: : (-17.727±13.850°,p= 0.002,p=0.012; hyprextension: right: (Z = -1.962°) ,p = 0.040, left: (-9.091±4.908°),p=0.010 ; articulatio cubiti: flexion: right: (10.455±10.829°), p= 0.009, left: (Z=-2,825), p=0.005 ; hyperextension: right: (Z=-2.236 °),p = 0.025, left: Z=(-2,00),p=0.046; articulatio radiocarpea :flexion right:(13.636±7.447°), p= 0.00, left; (Z=-2.829),p=0.005; hyperextension right: (Z = -2.754 ° ) , p = 0.006, left: (-9.091±4.908),p=0,00 . Conclusion: MENPORA elderly gymnastics training can increase the value of the upper limb joints\u27 ROM in Kemuning elderly group, Banyumanik, Semarang

On the accuracy of solving confluent Prony systems

In this paper we consider several nonlinear systems of algebraic equations which can be called "Prony-type". These systems arise in various reconstruction problems in several branches of theoretical and applied mathematics, such as frequency estimation and nonlinear Fourier inversion. Consequently, the question of stability of solution with respect to errors in the right-hand side becomes critical for the success of any particular application. We investigate the question of "maximal possible accuracy" of solving Prony-type systems, putting stress on the "local" behavior which approximates situations with low absolute measurement error. The accuracy estimates are formulated in very simple geometric terms, shedding some light on the structure of the problem. Numerical tests suggest that "global" solution techniques such as Prony's algorithm and ESPRIT method are suboptimal when compared to this theoretical "best local" behavior

Volatility of Linear and Nonlinear Time Series

Previous studies indicate that nonlinear properties of Gaussian time series with long-range correlations, $u_i$, can be detected and quantified by studying the correlations in the magnitude series $|u_i|$, i.e., the ``volatility''. However, the origin for this empirical observation still remains unclear, and the exact relation between the correlations in $u_i$ and the correlations in $|u_i|$ is still unknown. Here we find analytical relations between the scaling exponent of linear series $u_i$ and its magnitude series $|u_i|$. Moreover, we find that nonlinear time series exhibit stronger (or the same) correlations in the magnitude time series compared to linear time series with the same two-point correlations. Based on these results we propose a simple model that generates multifractal time series by explicitly inserting long range correlations in the magnitude series; the nonlinear multifractal time series is generated by multiplying a long-range correlated time series (that represents the magnitude series) with uncorrelated time series [that represents the sign series $sgn(u_i)$]. Our results of magnitude series correlations may help to identify linear and nonlinear processes in experimental records.Comment: 7 pages, 5 figure

The Central Timna Valley Project: 5 Years of Ongoing Textile Research

In its initial five years of activity the Central Timna Valley Project has dedicated its efforts to the excavation of several Late Bronze and Iron Age sites (13th-9th centuries BC) in the southern Arabah Valley of Israel (fig. 1).1 The project, headed by Erez Ben-Yosef of Tel Aviv University, explores the ancient exploitation of copper ores at Timna; these were utilised for the production of copper ingots that were traded throughout the southern Levant and possibly the greater Mediterranean region. It is within the strata of several newly excavated sites that a few hundred individual textile, cordage and rope fragments were uncovered

Catch and Length-Weight Relationship of Freshwater Lobster, Cherax Quadricarinatus Von Martens, 1868 in Tondano Lake, Kakas District, Minahasa, North Sulawesi

C. quadricarinatus (red claws) mempuyai nilai ekonomis penting baik komsumsi maupun sebagai krustasea hias dan telah banyak di budidaya serta di introduksi ke banyak perairan di luar habitat aslinya. Di Danau Tondano, C. quadricarinatus telah berkembang biak dan menjadi target penangkapan nelayan mengunakan alat tangkap bubu dan alat tangkap tura sejenis tombak sambil menyelam. Tujuan penelitinan ini ialah untuk mendeskripsikan penangkapan lobster air tawar C. quadricarinatus menggunakan alat tangkap bubu, hubungan panjang berat, pola pertumbuhan dan faktor kondisi. Hasil penilitian ini diharapkan dapat digunakan sebagai informasi keberadaan lobster air tawar C. quadricarinatus di Danau Tondano. Hasil tangkapan yang didapat adalah lobster air tawar, ikan Betutu, ikan Payangka, ika Mujair dan ikan Lele Dumbo. Hasil hubungan panjang berat lobster air tawar di dapat jantan : W=-1,8005+4,2765 log L, betina : W=-1,2978+3,6524 log L dan gabungan ( jantan & betina) : W=-1,5631+3,9848 log L. Pola pertumbuhan ketiganya ialah allometrik positif (A+) dan faktor kondisi jantan berkisar 0,60-1,43 dengan rata-rata1,071±0,17, betina berkisar 0,46-1,36 dengan rata-rata 1,027±0,18, dan gabungan (jantan dan betina) berkisar 0,59-1,642 dengan rata-rata1,22±0,21

Peningkatan Kemampuan Menganalisi Unsur Intrinsik Cerpen Melalui Pembelajaran Kooperatif Model Jigsaw Pada Siswa Kelas VII a SMP Budi Utama Tahun Pelajaran 2012/ 2013

This study is a classroom based action research. It aimed to improve the students’ ability in analyzing the intrinsic aspect of short story by implementing Cooperative learning, Jigsaw model. The study was conducted at class VII A SMP Budi Utama, in the academic year 2012/2013. Data was collected through observation (to find out the positive and negative attitude toward the process of teaching and learning) and test (to measure their ability in analyzing short story). The results shown that, there was improvement, in every cycle, on their ability in analyzing after having the treatment. In the pre-test, the score was 4,58. It increased respectively into 5,6 in cycle I, 6,22 in cycle II, and 7,5 in cycle III

Pemetaan Pemenuhan Standar Nasional Pendidikan dan Relevansi terhadap Kualitas Pembelajaran dan Ketuntasan Belajar Biologi di Sekolah Menengah Atas

Penelitian bertujuan untuk mengetahui profil pemenuhan standar nasional pendidikan dan hasil ujian nasional serta media dan proses belajar di salah satu sekolah menengah atas kabupaten sukoharjo. Metode yang digunakan dalam penelitian adalah metode survey dengan teknik pengumpulan data melalui angket, wawancara, dan observasi. Hasil penelitian menunjukkan profil keterpenuhan 8 SNP pada salah satu sekolah menengah atas di kabupaten sukoharjo sebesar 83,33 % dengan GAP tertinggi pada standar pendidik dan tenaga kependidikan (3,67 %) dan standar proses (3,24 %). Nilai ujian nasional memiliki rata-rata 5,92 dan pada proses pembelajaran kelas sebesar 81,82 %. Analisis profil buku guru dan siswa secara berturut-turut mendapatkan nilai sebesar 65 % dan 77 %. Hasil profil pemenuhan standar nasional pendidikan, hasil ujian nasional, media, dan proses belajar memberikan informasi yang dapat digunakan sebagai dasar untuk melakukan kegiatan penelitian